Freeze® is one of the coldest portable cryosurgical systems
available. A 3-6 second spray of cryogen, freezing for 20-30 seconds,
makes it a quick, easy and effective form of cryosurgery. With 2
forms of application- disposable CryoBuds® and reusable CryoCones®,
Verruca Freeze® is the clear choice for all your cryosurgical
most recent cryosurgery textbooks state that -50°C is adequate
to treat most benign skin lesions. Verruca-Freeze® delivers
freezing temperatures of -70°C, exceeding the minimum recommended
freezing temperatures. The FDA has cleared Verruca-Freeze® for
removal of 21 types of lesions including: warts, plantar warts,
venereal warts (condyloma acuminatum), seborrheic and actinic keratoses,
achrochordon (skin tags), molluscum contagiosum, age spots, dermatofibroma,
small keloids, granuloma annulare, porokeratosis plantaris, angiomas,
lentigo maligna, keratoacanthoma, lentigo discreta, chondrodermatitis,
epithelial nevus, leukoplakia and pyogenic granuloma. Lesion Descriptions
A range of different types of wart has been identified, varying
in shape and site affected, as well as the type of human papilloma
virus involved. These include:
wart (Verruca vulgaris): a raised wart with roughened surface, most
common on hands and knees.
Flat wart (Verruca plana): a small, smooth flattened wart,
flesh colored, which can occur in large numbers; most common on
the face, neck, hands, wrists and knees.
Filiform or digitate wart: a thread- or finger-like wart,
most common on the face, especially near the eyelids and lips.
Plantar wart (Verruca pedis): a hard sometimes painful lump,
often with multiple black specks in the center; usually only found
on pressure points on the soles of the feet.
Mosaic wart: a group of tightly clustered Plantar-type warts,
commonly on the hands or soles of the feet.
An actinic keratosis site may appear on any sun-exposed area, such
as the face, ears, neck, scalp, chest, backs of hands, forearms
or lips. Sites commonly range between 2 and 6 millimeters in size,
and can be dark or light, tan, pink, red, a combination of all these,
or have the same pigment as the surrounding skin.
A seborrheic keratosis (also known as Seborrheic Verruca)is a noncancerous
benign skin growth that originates in keratinocytes. Like liver
spots, seborrheic keratoses is seen more often as people age. S.K.
appears in various colors, from light tan to black. They are round
or oval in shape, feel flat or slightly elevated (like the scab
from a healing wound) and range in size from very small to more
than 2.5 centimeters (1.0 in) across. They can resemble warts, though
they have no viral origins. They can also resemble melanoma skin
cancer, though they are unrelated to melanoma.
Achrochordon is a small benign tumor that forms primarily in areas
where the skin forms creases, such as the neck, armpit and groin.
They may also occur on the face, usually on the eyelids. Acrochorda
are harmless and typically painless, and do not grow or change over
time. Though tags up to a half-inch long have been seen, they are
typically the size of a grain of rice. The surface of an acrochordon
may be smooth or irregular in appearance and is often raised from
the surface of the skin on a fleshy stalk called a peduncle.
Molluscum Contagiosu is a viral infection of the skin or occasionally
of the mucous membranes. This common viral disease has a higher
incidence in children, sexually active adults, and those who are
immunodeficient, and the infection is most common in children aged
one to ten years old. MC can affect any area of the skin but is
most common on the trunk of the body, arms and legs. It is spread
through direct contact or shared items such as clothing or towels.
Molluscum contagiosum lesions are flesh-colored, dome-shaped and
pearly in appearance. They are often 15 millimeters in diameter,
with a dimpled center. They are generally not painful, but they
may itch or become irritated. Picking or scratching the bumps may
lead to further infection or scarring. In about 10% of the cases,
eczema develops around the lesions. They may occasionally be complicated
by secondary bacterial infections. In some cases the dimpled section
may bleed once or twice.
Age spots are also known as sun spots, liver spots, Lentigos, or
Lentigines. These lesions are flat, tan, brown or dark brown spots
on sun-exposed skin. As people age, sun spots most commonly appear
on the backs of the hands, the forearms, neck, chest and face. Sun
spots are associated with cumulative sun exposure. The pigment producing
cells in the skin (called melanocytes) are activated to produce
more pigment (melanin) by ultraviolet rays. While these spots are
not themselves cancerous, you may be at risk for skin cancer if
you have them.
Condyloma (or Genital Warts) is a highly contagious sexually transmitted
disease caused by some sub-types of human papillomavirus (HPV).
It is spread through direct skin-to-skin contact during oral, genital,
or anal sex with an infected partner. Warts are the most easily
recognized symptom of genital HPV infection. Genital warts often
occur in clusters and can be very tiny or can spread into large
masses in the genital or penis area. In other cases they look like
small stalks. In women they occur on the outside and inside of the
vagina, on the cervix , the womb (uterus) or around (or inside)
the anus. They are approximately as prevalent in men but the symptoms
may be less obvious. When present, they usually are seen on the
tip of the penis. They also may be found on the shaft of the penis,
on the scrotum, or around (or inside) the anus. Rarely, genital
warts also can develop in the mouth or throat of a person who has
had oral sex with an infected person.
A dermatofibroma is a round, brownish to red-purple growth commonly
found on the legs. It is also called a histiocytoma. It can occur
anywhere, but seems to favor exposed areas. Dermatofibromas feel
like hard lumps under the skin. They're like an iceberg in that
there is more under the skin than seen on the surface. Often these
start out as red, turning later to brown, and sometimes itch. They
probably are a reaction to a minor injury, such as insect bites
or thorn pricks. Most commonly found on the leg.
A keloid (aka keloidal scar), is a type of scar, which depending
on its maturity, is composed of mainly either type III (early) or
type I (late) collagen. It is a result of an overgrowth of granulation
tissue (collagen type III) at the site of a healed skin injury which
is then slowly replaced by collagen type I. Keloids are firm, rubbery
lesions or shiny, fibrous nodules and can vary from pink to flesh-colored
or red to dark brown in color. A keloid scar is benign, non-contagious,
and sometimes accompanied by severe itchiness and pain, or changes
in texture. In severe cases, it can affect movement of the surrounding
Granuloma annulare may be pearly white, skin-colored, red or purple.
It is most often in an isolated area, but may appear as several
"bumps" spread over the body. Beginning as a round, firm,
smooth bump, the lesion becomes a circular ring with a clear center,
which resembles the shape of a doughnut. While granuloma annulare
can develop on any part of the skin it appears most often on the
tops of the hands and feet, elbows and knees. It usually does not
peel or itch and for that reason, can often go unnoticed.
Porokeratosis plantaris, palmaris, et disseminata: A very rare disorder
involving progressive skin thickening that starts with the palms
An angioma is any benign growth that consists of small blood vessels.
These tumors can be located anywhere on the body, and some of the
different types include spider angiomas, cherry angiomas and angiokeratomas.
Cherry angiomas and are due to aging and do not have any known significance.
Spider angiomas are more common in childhood and during pregnancy,
and a few can appear on anyone. When present in large numbers, they
may warn of liver damage. Angiokeratomas are an overgrowth of blood
vessels and skin cells.
Lentigo maligna is the non-invasive skin growth that some pathologists
consider to be a melanoma-in-situ. A few pathologists do not consider
lentigo maligna to be a melanoma at all, but a precursor to melanomas.
Once a lentigo maligna becomes a lentigo maligna melanoma, it is
treated as if it were an invasive melanoma.
Keratoacanthoma (KA) is a growth that is relatively common, benign
and most commonly found in elderly light-skinned individuals. It
is more common with individuals having an increased degree of sun
exposure and is often found at sites of previous injury or trauma.
It is not associated with internal malignancy, except in rare instances
where multiple keratoacanthomas are associated with a disease process
called Muir-Torre syndrome. KA is a rapidly growing growth on the
skin that expands from 1-2mm to 1-3cm over a few weeks, and develops
into a smooth dome-shaped growth with a central keratin core. If
untreated, KA's usually stop growing around 6-8 weeks, stay dormant
and unchanging for 2-6 weeks and then finally spontaneously regress
slowly over 2 to 12 months frequently healing with scarring. KA's
are most commonly found in the hands, arms, trunk and face.
A lentigo is a small, sharply circumscribed, pigmented macule surrounded
by normal-appearing skin. Histologic findings may include hyperplasia
of the epidermis and increased pigmentation of the basal layer.
A variable number of melanocytes are present; these melanocytes
may be increased in number, but they do not form nests. Lentigines
may evolve slowly over years, or they may be eruptive and appear
rather suddenly. Pigmentation may be homogeneous or variegated,
with a color ranging from brown to black.
Is a small, nodular, tender, chronic inflammatory lesion occurring
on the helix of the ear, occurring most often in men.
Epidermal nevi are hamartomas arising from the embryonic ectoderm
whose pluri potentialcells differentiate not only into keratinocytes
but also into the cell forming epidermal appendages. The lesions
may be deeply or slightly pigmented, have either a unilateral or
bilateral distribution, and often favour the extremities in what
appears to be a dermatomal distribution. They may also appear on
the oral mucosa and ocular conjunctiva. Onset is usually at birth
but may also occur in the second or third decade.
Leukoplakia is a clinical term used to describe patches of keratosis.
It is visible as adherent white plaques or patches on the mucous
membranes of the oral cavity, including the tongue. The clinical
appearance is highly variable. Leukoplakia is not a specific disease
entity, but is diagnosis of exclusion.
Pyogenic granuloma is a relatively common skin growth. It is usually
a small red, oozing and bleeding bump that looks like raw hamburger
meat. It often seems to follows a minor injury and grows rapidly
over a period of a few weeks to an average size of a half an inch.
The head, neck, upper trunk and hands and feet are the most commonly
sites; It can also be found on the lips, tongue and inner cheek.
Poor oral hygiene or trauma are usually precipitating factors. It
is seen most often in children, pregnant women and those taking
the drugs Indinavir, Soriatane, Accutane and oral contraceptives.
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